Peyronie's disease is a disease characterized by plaque formations in the membrane (tunica albuginea) that surrounds the penis and contributes to erection. Having some rheumatic diseases such as previous trauma, testosterone deficiency, Diabetes disease, Hypertension, vascular diseases, previous prostate cancer surgery, Dupuytren's contracture may lead to the development of Peyronie's Disease. Inflammation areas secondary to repetitive microtraumas in the tunica are the main blamed mechanism at the onset of the disease.
Plaques create different symptoms in two stages, acute or chronic. The first stage, called the acute phase, causes complaints in the form of burning, pain sensation and palpable stiffness in the penis, especially during erection and when the plaque is newly formed.
In the chronic stage, while the pain in the penis tends to decrease, the deformation of the penis becomes more pronounced. Penile curvature is the most common finding. The curvature is usually upwards. Shortening, thinning, deformity, hourglass-like appearance may occur in the penis. Erectile dysfunction can also occur in the chronic phase of the disease.